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Fenbendazole

Fenbendazole Overview:

Fenbendazole is a Benzimidazole with a chemical structure very similar to Mebendazole, which is a broad-spectrum anthelmintic medication primarily used in veterinary medicine to treat parasitic infections in animals such as dogs, cats, horses, and livestock. It is classified as a benzimidazole, which works by inhibiting the ability of parasites to absorb nutrients, effectively killing them. The drug is generally used to treat infections caused by roundworms, hookworms, tapeworms, and other intestinal parasites.

Chemical Structure and Mechanism of Action

Fenbendazole works by binding to tubulin, a protein that forms microtubules, which are essential for cell division and other cellular processes. By disrupting microtubule formation, fenbendazole impairs the function of the parasite’s cells, leading to their death.

Off-Label Use of Fenbendazole for Cancer Treatment

Although the anti-parasitic Fenbendazole is not FDA-approved for human use, there is extensive evidence of anti-cancer effects in the published literature, both in vitro and in vivo, and this is not a controversial medication, as it has been made out to be (Makis 2024).

Proposed Mechanisms in Cancer:

Fenbendazole's potential anticancer effects are thought to stem from its ability to interfere with microtubules and other cellular processes in cancer cells. The following mechanisms are proposed:

  1. Inhibition of Cell Division: Like its action in parasites, fenbendazole inhibits microtubule formation in cancer cells, disrupting mitosis (cell division) and leading to cell death.

  2. Apoptosis Induction: Some studies have shown that fenbendazole promotes apoptosis (programmed cell death) in cancer cells, this is still a topic of further investigation.

  3. Anti-Angiogenesis: There is evidence that fenbendazole reduces the growth of blood vessels (angiogenesis) that supply tumors, thus limiting tumor growth.

  4. Immune System Modulation: Fenbendazole has effects on the immune system, enhancing the body's ability to recognize and destroy cancer cells, this mechanism remains under investigation.

Research and Evidence:

  • Animal Studies: In some animal models, fenbendazole has shown potential in reducing tumor growth. For example, a study in mice suggested that fenbendazole might have synergistic effects when combined with other chemotherapy drugs.

  • In Vitro Studies: Lab-based studies on human cancer cell lines have demonstrated that fenbendazole can inhibit the growth of various cancer cells, including breast, lung, and colon cancer cells.

  • Human Anecdotal and Case Report Evidence: Many cancer patients, particularly those seeking alternative therapies, have reported successfully using fenbendazole as part of their treatment regimen. One high-profile case involved a man named Joe Tippens, who, after using fenbendazole along with other treatments, reported remission of his terminal cancer. A case report series published in SciTechnol (Chiang, et al., 2021) Concluded Fenbendazole appears to be a potentially safe and effective antineoplastic agent that can be repurposed for human use in treating genitourinary malignancies.

Safety and Side Effects

  • Fenbendazole has an excellent safety profile and its close relative, Mebendazole is FDA approved, and it’s undergoing several Clinical Trials for Cancer Treatments in the US right now, including colon cancers and brain cancers (Makis 2024).

  • Side effects can occur, including nausea, diarrhea, or lethargy, especially in cases of overdose.

  • Monitor for liver and kidney function, particularly with long-term or high-dose use.

Important Reference Links For More Information:

The first 2 links review 22 different Benzimidazole (Fenbendazole & Mebendazole) papers and the 3rd covers 3 published case studies:

DISCLAIMER

Statements on this website have not been evaluated by the Food and Drug Administration. The contents of this website is for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

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